An Inverse EEG Problem Solving Environment and its Applications to EEG Source Localization

BioPSE is a scientific programming environment that allows the interactive construction, debugging, and steering of large-scale scientific computations. BioPSE can be envisioned as a “computational workbench,” in which a scientist can design and modify simulations interactively via a dataflow programming model. As opposed to the typical “off-line” simulation mode (in which the scientist manually sets input parameters, computes results, visualizes the results via a separate visualization package, and then starts again at the beginning), BIoPSE “closes the loop” and allows interactive steering of the design, computation, and visualization phases of a simulation. A snapshot of our source localization algorithm running within the BioPSE environment is shown in Fig. . We demonstrate the application of BioPSE to the construction of an EEG cost field for FEM a realistic head model, and single dipole source localization using the downhill simplex method.